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Due to the similar degree of inhibition of adenosine uptake at these plasma concentrations, this food effect is not considered clinically relevant Take this medication with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Due to the similar degree of inhibition of adenosine uptake at these plasma concentrations, this food effect is not considered clinically relevant Take this medication with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. If you have certain side effects (such as severe headache) when you first start taking this medication, your doctor may temporarily change your dose Aggrenox has an average rating of 6. If you have certain side effects (such as severe headache) when you first start taking this medication, your doctor may temporarily change your dose Aggrenox has an average rating of 6. Your healthcare provider will tell you how many Aggrenox to take and when to take them. 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